Description

Specifications

• Form: White lyophilized powder
• Standard vial size: 5mg
• Purity: ≥99% (HPLC & Mass Spec verified)
• Sequence: 37-amino-acid cathelicidin-family antimicrobial peptide
• Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
• CAS Number: 211427-08-6

Overview

LL-37 is the only cathelicidin-family antimicrobial peptide expressed in humans, released from neutrophils, epithelial cells, and macrophages as part of the innate immune system’s first line of defense.

Mechanism & Research Findings

LL-37 exerts broad-spectrum antimicrobial activity by directly disrupting bacterial cell membranes through an amphipathic, cationic alpha-helical structure that inserts into and permeabilizes lipid bilayers. Beyond direct antimicrobial action, it is studied for immunomodulatory roles including chemoattraction of immune cells, promotion of angiogenesis, and wound-healing signaling, making it a heavily referenced compound in both antimicrobial-peptide and innate-immunity research literature.

Research Applications

• Antimicrobial peptide / membrane-disruption mechanism research
• Innate immune-cell chemoattraction studies
• Wound-healing and angiogenesis-adjacent immune signaling

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.