Description

Specifications

• Form: White lyophilized powder
• Standard vial size: 5mg / 10mg
• Purity: ≥99% (HPLC & Mass Spec verified)
• Sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2
• Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted, use within 30 days
• CAS Number: 170851-70-4

Overview

Ipamorelin is a highly selective pentapeptide GH secretagogue, developed specifically to isolate GH release from the off-target cortisol, prolactin, and appetite effects seen with earlier GHRPs. This selectivity has made it one of the most-cited GHRPs in modern receptor-selectivity literature.

Mechanism & Research Findings

Ipamorelin selectively activates GHS-R1a with minimal cross-reactivity at other pituitary receptors, producing GH release without the meaningful cortisol/prolactin elevation associated with GHRP-2 or GHRP-6 in comparative studies. This clean pharmacological profile has made it a preferred tool for isolating GH-axis effects from confounding hormonal noise in research design, and it is commonly studied in stacked protocols with CJC-1295 to examine synergistic GHRH/GHS-R1a receptor activation.

Research Applications

• Selective GHS-R1a receptor studies
• GH-axis synergy research (paired with GHRH analogs)
• Bone density and musculoskeletal preclinical models
• Comparative secretagogue selectivity studies

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.