Description
Specifications
- Form: White lyophilized powder
- Standard vial size: 50mg
- Purity: ≥99% (HPLC & Mass Spec verified)
- Class: Nucleotide analog, AMPK activator
- Storage: Store lyophilized powder at -20°C, protect from light; refrigerate at 2–8°C once reconstituted
- CAS Number: 2627-69-2
Overview
AICAR is a cell-permeable nucleoside analog and one of the most widely used tool compounds in AMPK-pathway research, valued for its ability to pharmacologically activate this key metabolic switch independent of upstream signaling.
Mechanism & Research Findings
AICAR is taken up by cells and converted to ZMP, an AMP-mimetic that directly activates AMPK, the master regulator of cellular energy homeostasis. Once activated, AMPK signaling shifts cellular metabolism toward catabolic, energy-generating pathways (fatty-acid oxidation, glucose uptake) while suppressing energy-consuming anabolic processes. AICAR is a foundational reference compound across metabolic-disease, exercise-mimetic, and skeletal-muscle fiber-type research literature.
Research Applications
- AMPK pathway activation research
- Exercise-mimetic and skeletal-muscle metabolism studies
- Glucose-uptake and fatty-acid-oxidation research
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.



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