Description
Specifications
- Form: White lyophilized powder
- Standard vial size: 10mg
- Purity: ≥99% (HPLC & Mass Spec verified)
- Sequence: Aromatic-cationic tetrapeptide, D-Arg-2′,6′-Dmt-Lys-Phe-NH2
- Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
- CAS Number: 736992-21-5
Overview
SS-31 is a synthetic aromatic-cationic tetrapeptide engineered specifically to concentrate in the inner mitochondrial membrane, developed and studied extensively for its interaction with cardiolipin, a phospholipid essential to mitochondrial membrane integrity.
Mechanism & Research Findings
SS-31 selectively binds cardiolipin in the inner mitochondrial membrane, where it is studied for stabilizing cristae architecture and reducing cardiolipin peroxidation, thereby supporting electron-transport-chain efficiency and reducing reactive-oxygen-species generation in preclinical mitochondrial-dysfunction models. It has become one of the leading reference compounds in mitochondrial-medicine research spanning cardiac, renal, and skeletal-muscle tissue.
Research Applications
- Cardiolipin binding and inner-mitochondrial-membrane research
- Electron-transport-chain efficiency and ROS-reduction studies
- Mitochondrial-dysfunction disease modeling
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.



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