FOX04 -DRI

Identity & specification

Amount in vial

Contents

fox04-dri

Purity

>99%

SKU

fox04-dri

5 or more 5%
10 or more 10%
50 or more 20%
100 or more 25%

£49.99 £99.99Price range: £49.99 through £99.99

Purity

≥99%

Storage

Refrigerate 2–8°C

COA

With every order

Use

Research only

For research use only. Not for human or veterinary use, diagnostic procedures, or food applications. Buyer assumes all responsibility for safe handling and lawful use.

Description

Specifications

  • Form: White lyophilized powder
  • Standard vial size: research-grade, typically supplied in mg quantities
  • Purity: ≥99% (HPLC & Mass Spec verified)
  • Class: Cell-penetrating D-retro-inverso peptide, FOXO4-p53 interaction disruptor
  • Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted

Overview

FOX04-DRI is a cell-penetrating peptide engineered in a D-retro-inverso configuration (protecting it from rapid proteolytic degradation) that disrupts the interaction between FOXO4 and p53 specifically within senescent cells, a compound at the center of “senolytic” cellular-aging research.

Mechanism & Research Findings

In senescent cells, FOXO4 binds and sequesters p53 in the nucleus, blocking p53-driven apoptosis and allowing senescent cells to persist (“zombie cells”). FOX04-DRI competitively disrupts this FOXO4-p53 interaction, freeing p53 to trigger apoptosis selectively in senescent cells while sparing healthy, non-senescent tissue in published mouse models — a mechanism widely cited as a foundational proof-of-concept for peptide-based senolytic research.

Research Applications

  • Cellular senescence and senolytic pathway research
  • FOXO4-p53 protein-interaction studies
  • Selective senescent-cell apoptosis modeling

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.

Additional information

Dosage

10mg, 2mg

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