Description
Specifications
- Form: White lyophilized powder
- Standard vial size: research-grade, typically supplied in mg quantities
- Purity: ≥99% (HPLC & Mass Spec verified)
- Class: Stabilized spadin-derived peptide fragment
- Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
Overview
PE-22-28 is a cyclized, protease-resistant derivative of spadin, a peptide studied for its selective antagonism of the TREK-1 potassium channel — a target of significant interest in neuroscience research.
Mechanism & Research Findings
PE-22-28 selectively blocks TREK-1, a two-pore-domain potassium channel highly expressed in the central nervous system that regulates neuronal excitability. TREK-1 antagonism has been studied in rodent models for its effects on hippocampal neuroplasticity and behavioral despair assays, with the cyclized structure of PE-22-28 offering substantially improved metabolic stability over native spadin, allowing for more consistent research dosing profiles in longer-duration studies.
Research Applications
- TREK-1 potassium channel pharmacology
- CNS excitability and neuroplasticity research
- Rodent behavioral-assay research
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.



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