PE-22-28

Identity & specification

Amount in vial

Contents

pe-22-28

Purity

>99%

SKU

pe-22-28

5 or more 5%
10 or more 10%
50 or more 20%
100 or more 25%

€29.25 €40.96Price range: €29.25 through €40.96

Purity

≥99%

Storage

Refrigerate 2–8°C

COA

With every order

Use

Research only

For research use only. Not for human or veterinary use, diagnostic procedures, or food applications. Buyer assumes all responsibility for safe handling and lawful use.

Description

Specifications

  • Form: White lyophilized powder
  • Standard vial size: research-grade, typically supplied in mg quantities
  • Purity: ≥99% (HPLC & Mass Spec verified)
  • Class: Stabilized spadin-derived peptide fragment
  • Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted

Overview

PE-22-28 is a cyclized, protease-resistant derivative of spadin, a peptide studied for its selective antagonism of the TREK-1 potassium channel — a target of significant interest in neuroscience research.

Mechanism & Research Findings

PE-22-28 selectively blocks TREK-1, a two-pore-domain potassium channel highly expressed in the central nervous system that regulates neuronal excitability. TREK-1 antagonism has been studied in rodent models for its effects on hippocampal neuroplasticity and behavioral despair assays, with the cyclized structure of PE-22-28 offering substantially improved metabolic stability over native spadin, allowing for more consistent research dosing profiles in longer-duration studies.

Research Applications

  • TREK-1 potassium channel pharmacology
  • CNS excitability and neuroplasticity research
  • Rodent behavioral-assay research

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.

Additional information

Dosage

10mg, 5mg

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