Description

Specifications

• Form: White lyophilized powder
• Standard vial size: 10mg
• Purity: ≥99% (HPLC & Mass Spec verified)
• Sequence: Mitochondrial-derived peptide, 16 amino acids, encoded within the 12S rRNA mitochondrial gene
• Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
• CAS Number: 1627580-64-6

Overview

MOTS-c is a mitochondrial-derived peptide (MDP) encoded by a small open reading frame within mitochondrial DNA rather than the nuclear genome, representing a distinct and comparatively recently discovered class of cell-signaling peptides.

Mechanism & Research Findings

MOTS-c is studied for its ability to translocate to the nucleus under metabolic stress and regulate nuclear gene expression, notably activating AMPK signaling — a central cellular energy-sensing pathway — and influencing folate-methionine cycle metabolism. Research in exercise-physiology and metabolic-disease models has examined its role in insulin sensitivity and skeletal-muscle metabolic adaptation, making it a key reference compound in the emerging mitochondrial-derived-peptide research field.

Research Applications

• AMPK pathway and cellular energy-sensing research
• Mitochondrial-nuclear communication studies
• Skeletal-muscle metabolic adaptation and insulin-sensitivity models

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.