Description

Specifications

• Form: White lyophilized powder
• Standard vial size: 10mg
• Purity: ≥99% (HPLC & Mass Spec verified)
• Sequence: Tripeptide, Lys-Pro-Val (C-terminal fragment of alpha-MSH)
• Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
• CAS Number: 63959-59-7

Overview

KPV is the smallest active fragment of alpha-melanocyte-stimulating hormone (α-MSH), retaining the anti-inflammatory signaling of the parent hormone without its pigmentation or appetite-related receptor activity.

Mechanism & Research Findings

Unlike the melanocortin-receptor-mediated effects of full-length α-MSH, KPV’s anti-inflammatory activity in research models appears largely melanocortin-receptor-independent, with studies pointing to direct modulation of NF-κB signaling — a master regulator of the inflammatory cascade. This has made KPV a compound of interest in gut-inflammation and dermatological research models, including studies on colitis and inflammatory skin conditions, where researchers are specifically interested in anti-inflammatory activity without melanocortin-driven pigmentation effects.

Research Applications

• NF-κB pathway and inflammation signaling research
• Gut-barrier / colitis animal models
• Dermatological inflammation research

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.