Description

Specifications

• Form: White lyophilized powder
• Standard vial size: 5mg / 10mg
• Purity: ≥99% (HPLC & Mass Spec verified)
• Sequence: Modified GRF(1-29), tetrasubstituted for enhanced stability
• Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted, use within 20-30 days
• CAS Number: 863288-34-0

Overview

CJC-1295 without DAC (also called Mod GRF 1-29) is a modified fragment of growth hormone releasing hormone engineered with amino acid substitutions that resist enzymatic degradation, giving it a longer half-life in solution than native GHRH(1-29) while retaining receptor activity.

Mechanism & Research Findings

This analog binds the GHRH receptor on pituitary somatotrophs, stimulating synthesis and pulsatile release of growth hormone through the cAMP/PKA signaling cascade. Because it lacks the Drug Affinity Complex (DAC) moiety, its research half-life is measured in minutes to hours rather than days, making it useful in studies that require GH pulses that mimic natural secretory rhythms rather than sustained receptor occupancy. It is one of the most common reference GHRH analogs used alongside GHRPs (Ipamorelin, GHRP-2/6) in combined GH-axis synergy research.

Research Applications

• GHRH receptor pharmacology and cAMP signaling studies
• Pulsatile GH-secretion modeling
• Combination studies with GHS-R1a agonists

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.