Description

Specifications

• Form: White lyophilized powder
• Standard vial size: 10mg
• Purity: ≥99% (HPLC & Mass Spec verified)
• Sequence: 24-amino-acid mitochondrial-derived peptide, encoded within the mitochondrial 16S rRNA gene
• Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted

Overview

Humanin was the first mitochondrial-derived peptide discovered and remains the most extensively studied member of this peptide class, originally identified in a screen for factors protecting neurons from Alzheimer’s-disease-related toxicity.

Mechanism & Research Findings

Humanin is studied for cytoprotective signaling through multiple pathways, including binding to the CHRNA7/WSX-1/gp130 receptor complex to activate STAT3 signaling, as well as direct interaction with pro-apoptotic Bax protein to inhibit mitochondrial-mediated apoptosis. Research has examined its neuroprotective activity in models of neurodegeneration, along with broader roles in cellular-stress resistance, positioning it as the foundational reference compound in mitochondrial-derived-peptide and cytoprotection research.

Research Applications

• STAT3 signaling and cytoprotection research
• Apoptosis (Bax pathway) inhibition studies
• Neurodegeneration and neuroprotection modeling

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.