Description
Specifications
- Form: White lyophilized powder
- Standard vial size: 10mg
- Purity: ≥99% (HPLC & Mass Spec verified)
- Sequence: Cyclic heptapeptide, MC3R/MC4R-selective metabolite of Melanotan II
- Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
- CAS Number: 189691-06-3
Overview
PT-141 is a metabolite of Melanotan II, engineered to selectively retain MC3R/MC4R receptor activity while minimizing MC1R-mediated pigmentation effects, and is one of the most clinically referenced melanocortin peptides in sexual-behavior neuroscience research.
Mechanism & Research Findings
By selectively activating MC4R in the hypothalamus, PT-141 is studied for its central (rather than vascular) mechanism of action in sexual-arousal pathway research — a key distinction from PDE5-inhibitor research compounds, which act peripherally. Clinical trial literature (leading to eventual approval for a related indication) has characterized its dose-response and receptor-binding profile in detail, making it a frequently referenced compound in central melanocortin-pathway and neuroendocrine arousal research.
Research Applications
- Central MC3R/MC4R receptor pathway research
- Hypothalamic sexual-arousal signaling studies
- Comparative central vs. peripheral arousal-pathway research
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.


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