Description
Specifications
- Form: White lyophilized powder
- Standard vial size: 10mg
- Purity: ≥99% (HPLC & Mass Spec verified)
- Class: Non-erythropoietic EPO-derived peptide fragment
- Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
Overview
P21 is a short synthetic peptide derived from the helix-B region of erythropoietin, studied — like ARA-290 — for tissue-protective signaling separate from EPO’s classical hematopoietic activity, with particular research focus on neuroprotection.
Mechanism & Research Findings
P21 is studied for activity at the innate repair receptor complex, similarly to other helix-B-derived EPO fragments, and has been examined in preclinical models of traumatic brain injury and ischemic neuronal damage for its capacity to reduce neuronal apoptosis and support recovery of motor and cognitive function without affecting hematocrit. It is frequently studied comparatively alongside ARA-290 to map structure-activity relationships within this EPO-fragment peptide family.
Research Applications
- Traumatic brain injury and ischemic neuroprotection research
- Innate repair receptor pathway studies
- Comparative EPO-fragment structure-activity research
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.


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