Description
Specifications
- Form: White lyophilized powder
- Standard vial size: 10mg
- Purity: ≥99% (HPLC & Mass Spec verified)
- Sequence: Cyclic heptapeptide analog of alpha-MSH
- Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
- CAS Number: 121062-08-6
Overview
Melanotan II is a cyclic, non-selective melanocortin receptor agonist, engineered from alpha-MSH for enhanced potency and metabolic stability, and is one of the most widely studied melanocortin peptides in receptor-pharmacology literature.
Mechanism & Research Findings
Unlike the more selective MT-1, MT-2 activates multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R), producing pigmentation effects through MC1R alongside separate research-documented effects on appetite suppression (MC4R) and sexual-behavior pathways (MC3R/MC4R) in animal models. This broad receptor activity has made MT-2 a key reference compound for characterizing melanocortin receptor subtype functions and is the parent compound from which PT-141 (bremelanotide) was pharmacologically developed.
Research Applications
- Multi-receptor melanocortin pharmacology (MC1R/MC3R/MC4R)
- Appetite-regulation pathway research
- Comparative receptor-subtype selectivity studies
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.


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