Description

Specifications

• Form: White lyophilized powder
• Standard vial size: 5mg
• Purity: ≥99% (HPLC & Mass Spec verified)
• Sequence: Modified fragment of human GH (hGH 176-191) with a stabilizing tyrosine addition
• Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted
• CAS Number: 221231-10-3

Overview

AOD9604 is a modified fragment of the C-terminal region of human growth hormone, engineered to isolate the lipolytic (fat-metabolizing) region of the GH molecule from its growth-promoting regions.

Mechanism & Research Findings

Native GH’s lipolytic activity is localized to its 176-191 fragment. AOD9604 stabilizes this fragment with an additional tyrosine residue, allowing researchers to study fat-metabolism signaling in isolation from the IGF-1-mediated growth effects of full-length GH. In preclinical models, it has been studied for its effects on lipolysis and inhibition of lipogenesis without meaningfully affecting blood glucose or IGF-1 levels, making it a useful tool compound for dissecting GH’s pleiotropic effects.

Research Applications

• Isolated lipolytic-domain GH research
• Adipocyte metabolism and lipogenesis-inhibition studies
• Comparative studies vs. full-length GH signaling

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.