Description

Specifications

• Form: White lyophilized powder
• Standard vial size: 5mg
• Purity: ≥99% (HPLC & Mass Spec verified)
• Sequence: D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2
• Storage: Store lyophilized powder at -20°C; refrigerate at 2–8°C once reconstituted, use within 30 days
• CAS Number: 158861-67-7

Overview

GHRP-2 (pralmorelin) is a synthetic hexapeptide belonging to the growth hormone releasing peptide family. Developed as a more potent and metabolically stable successor to earlier ghrelin-mimetic compounds, GHRP-2 is one of the most extensively characterized GH secretagogues in laboratory research, valued for its strong, reproducible GH pulse induction in animal and in-vitro models.

Mechanism & Research Findings

GHRP-2 acts as an agonist at the growth hormone secretagogue receptor (GHS-R1a) in the hypothalamus and pituitary, triggering a robust, dose-dependent release of growth hormone through a pathway distinct from — and synergistic with — GHRH receptor signaling. Preclinical studies have documented its ability to mildly increase circulating cortisol and prolactin alongside GH, a distinguishing feature researchers use when comparing secretagogue selectivity across the GHRP class. Investigators frequently pair GHRP-2 with GHRH analogs such as CJC-1295 or Sermorelin in stacked research protocols to study synergistic GH-axis activation.

Research Applications

• Growth hormone axis and pituitary signaling studies
• Ghrelin receptor pharmacology research
• Comparative secretagogue potency studies (vs. GHRP-6, Ipamorelin, Hexarelin)
• Appetite and metabolic hormone interaction research

Availability note: GHRP-2 supply can fluctuate; GHRP-6 and Ipamorelin are closely related in-stock alternatives for GHS-R1a research.

For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.